UPR 5301

Centre de recherches sur les macromolécules végétales

Created in 1966 under the supervision of CNRS, the Centre de Recherches sur les Macromolecules Vegetales (CERMAV) is a fundamental research center devoted to Glycosciences, with strong and multidisciplinary expertise that spans from chemistry, physical-chemistry, biology to material sciences. It covers all the areas related to carbohydrates, their in vivo and in vitro synthesis, their characterization, and their functions and applications. Specifically, the main research area of CERMAV is devoted to the studies of saccharidic molecules: sugars, oligosaccharides and polysaccharides, glycoproteins and glycomaterials.

Supramolecular assembly and chirality of synthetic carbohydrate materials

We have just published the results of our international collaboration with MPI-Potsdam (Germany) in Angewandte Chemie International Edition. In this work, we built a model carbohydrate material system based on synthetic gluycose disaccahrdes. Microcrystal electron diffraction (microED) analysis revealed that the synthetic disaccharides formed highly crystalline helical fiber. The chirality of the assembled helical fibers can be tunable by changing the enantiomeric structure of the disaccharides, underlining the potential of designer carbohydrate materials for nanotechnology applications.

Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity

We have just published the results of our international collaboration with Aarhus University (DK), University of Cambridge (UK), University of Copenhagen (DK), University of Otago (NZ) in the prestigious journal Science. This work reports for the first time how, legumes (soybean, alfalfa, peas...) have established a beneficial symbiosis with soil bacteria that fix nitrogen, a key nutrient, by a subtle structural evolution of a receptor common to all terrestrial plants. These results open up major prospects for the development of more sustainable agriculture by reducing the use of nitrogen fertilizers.

Lipo-chitooligosaccharides as regulatory signals of fungal growth and development

We have just published the results of our international collaboration with American Universities (University of Wisconsin – Madison, University of Tennessee - Knoxville, University of California - Santa Barbara) and Toulouse laboratories (CNRS, University of Toulouse, IRD, INRAE) in the prestigious journal Nature communications. Our work shows that lipo-chitooligosaccharides (LCOs), which are signaling molecules produced by rhizobial bacteria and by certain fungi that also establish symbiotic relationships with plants, are actually produced by many species of fungi. Our results suggest that LCOs production is common among fungi and that oligosaccharides may function as signals regulating the growth and development of fungi.

Drug carrier systems made from self-assembled glyco-nanoparticles of maltoheptaose-b-polyisoprene enhanced the distribution and activity of curcumin against cancer cells

We have just published the results of our international collaboration with Brazil and in particular Universidade Estadual de Maringá, Universidade Tecnológica Federal do Paraná and Universidade Federal do Piauí, about the manufacture of carrier systems for drugs, from glyco- self-assembled nanoparticles. Our work improves the distribution and activity of curcumin against cancer cells.