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Chemistry and Biotechnology of Oligosaccharides
The CBO team's research focuses on the development of chemical and enzymatic tools for the production of glycans (oligo-, polysaccharides) and glycoconjugates
Polysaccharides Structure and Biodegradation
The objectives of the team “Polysaccharide structure and biodegradation” are to participate to the worldwide effort to attribute the function of genes encoding putative polysaccharide degrading enzymes and to decipher the degradation of complex polysaccharides by PULs. The discovery of new enzymes will help to the structural characterization of the polysaccharide diversity and provide new oligosaccharides as potential bioactive compounds.
Self-Assembly of Glycopolymers
The objective of the research project is the development of synthesis strategies to precisely modify biosourced carbohydrates in order to bring new functionalities. For instance, some of the goals are to produce polysaccharide mimetics, electrospun glyco-nanofibers, self-assembled glyco-nanoparticles and thin films or carbohydrate coatings via surface biomimicry for a variety of applications: molecular recognition (sugars, proteins), biosensors, selective filtration, control released, drug delivery, new lithographic template (biodegradable saccharide mask), flexible electronics (conducting glycopolymers), etc.
Structural and molecular glycobiology
The structural and molecular glycobiology team aims to unravel the structure/function relationships of proteins with complex glycans such as glycoconjugates and polysaccharides
It uses a multidisciplinary approach of structural glycobiochemistry. Its research activity is conducted along three main topics:
-The biosynthesis of complex carbohydrates by glycosyltransferases (GTs).
-The recognition of glycoconjugates by lectins.
-The biological activity of oligo- and polysaccharides.
Structure and modification of polysaccharides
The research in the SMP group is focused on the structural characterization of oligo-and polysaccharides, their selective chemical modification and the build-up of new polysaccharide materials for different applications.
Structure and properties of glycomaterials
The research developed in this team concerns the polysaccharides in the semi-crystalline solid state (cellulose, starch, chitin, etc.): their morphology, structure and intrinsic properties, their organization within natural organisms as well as their applicatibility potential in order to design new materials via their functionalization and / or their self-assembly and / or the development of new processes.